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KMID : 1001020220200030186
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Journal of Urologic Oncology
2022 Volume.20 No. 3 p.186 ~ p.196
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Comparison of Perioperative and Oncologic Outcome Between Old Versus Oldest Old After Radical Cystectomy for Bladder Cancer
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Park Sang-Soo
Lee Chung-Un
Chung, Jae-Hoon
Song Wan
Kang Min-Yong
Sung Hyun-Hwan
Jeon Hwang-Gyun
Seo Seong-Il
Jeon Seong-Soo
Lee Hyun-Moo
Jeong Byong-Chang
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Abstract
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Purpose: The purpose of study was to compare oncologic outcomes (recurrence-free survival [RFS], cancer-specific survival [CSS], and overall survival [OS]) and early complication (within 30 days) after radical cystectomy (RC) between old patients (70?79 aged) and oldest-old patients (above 80).
Materials and Methods: This retrospective study reviewed total 340 patients with urothelial carcinoma of bladder who received RC between November 1996 and December 2018. The patients were divided into 2 groups by age, 307 patients aged 70?79 and 33 patients aged above 80. Baseline characteristics, perioperative outcomes and early complication were compared between the 2 groups. Kaplan?Meier (K-M) survival analysis was used to estimate RFS, CSS, OS, and multivariable Cox proportional hazard models were used to identify factors predicting RFS, CSS, OS.
Results: The results of both groups did not statistically differ from each other in most clinicopathologic baseline characteristics and perioperative information. Both groups showed similar 30-day complication rates (59.3% vs. 60.3%, p=0.210). K-M showed 3-year survival rate, RFS was shorter in oldest-old group (41.4% vs. 56.7%) but not statistically different (p=0.063). Oldest-old group showed similar 3-year CSS (78.1% vs. 74.6%, p=0.779) but worse OS (51% vs. 58%, p=0.047) compared with the old group. Common factor affecting RFS, CSS, and OS were T stage and N stage (all p<0.05). Age is not factor affecting RFS, CSS, and OS.
Conclusions: Oldest-old who received RC had similar perioperative, oncologic outcome and complication compared with the seventies. RC could be considered treatment option for selected oldest-old patients.
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KEYWORD
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Radical cystectomy, Octogenarians, Bladder cancer, Survival, Complications
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